Disease

Neurological Disease Mechanisms and Treatments

3 developments in the corpus

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SEP 2, 2026 · JOURNAL ARTICLE

Vascular cognitive impairment and dementia: current understanding and future directions

npj Dementia

A narrative review synthesizing mechanistic, epidemiologic, and translational evidence on vascular dementia pathways and prevention strategies, without new primary data or clinical trial results.

Expert GuidanceNeurological Disease Mechanisms and Treatments Shivi Garg Cerebrovascular and Genetic Disorders

Reported

Global dementia prevalenceover 55 million individuals worldwide

Projected change in dementia prev…triple

VaD proportion of all dementia ca…roughly 20%

AUG 10, 2026 · JOURNAL ARTICLE

Deletion of RGS5 attenuates high-fat diet-induced cerebrovascular pathology and associated spatial memory deficits

Brain Behavior and Immunity

A sound but limited preclinical study in knockout mice showing RGS5 deletion prevents diet-induced cerebrovascular pathology and spatial memory deficits, needing confirmation in larger or human studies.

PromisingNeurological Disease Mechanisms and Treatments Osama F. Elabi Alba M. García-Serrano

Reported

Diet duration23 weeks

Primary endpointSpatial memory preserved in RGS5-KO, impair…

JUL 31, 2026 · JOURNAL ARTICLE

Current trends in computational mapping and anatomical classification of the hippocampal arterial supply

Bioinformation

A narrative review of computational methods for hippocampal vascular imaging with no original data, efficacy comparisons, or clinical validation—describes potential rather than demonstrated clinical utility.

Hypothesis-GeneratingNeurological Disease Mechanisms and Treatments Dementia and Cognitive Impairment Research P.R. Chauhan