AUG 11, 2026 · JOURNAL ARTICLE
Ultra-sensitive profiling of CRISPR-Cas off-target effects with Tracking-seq2
Nature Communications
A methodological advance in detection sensitivity for CRISPR off-target effects in primary human cells, demonstrated across multiple editor types, but without clinical outcome data or comparative effectiveness trial.
Study details
DesignTechnology development and validation study
InterventionTracking-seq2: integration of exogenous 5′…
ComparatorCurrent state-of-the-art off-target detecti…