SEP 1, 2026 · JOURNAL ARTICLE
729. From metabolic dysregulation and shared genetic etiology to suicidality: the psychiatric promise and safety debate of GLP-1 receptor agonists
The International Journal of Neuropsychopharmacology
This is a narrative evidence synthesis proposing mechanistic links between metabolic dysfunction and suicidality, and raising testable hypotheses about GLP-1RA effects on psychiatric outcomes; it does not report original trial results or definitive causal evidence, but rather integrates existing literature to frame future research directions.
Reported
Systematic review sample144 randomised trials
Semaglutide dose evaluated2.4 mg