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Mechanistic modeling study using computational predictions and limited empirical validation (murine model and observational human trial) to propose metabolic niche complementarity as a predictor of FMT outcomes; results are not yet confirmatory in clinical practice.
Single-center pilot case series of n=3 with no comparator; demonstrates feasibility and clinical signal in a high-risk population but requires confirmation in larger controlled studies before informing practice.
A real observation from a sound but limited case-control study examining risk factors for a rare disease in infants, supported by mechanistic microbiome data and animal model findings, but requiring confirmation in larger prospective studies.
A narrative review synthesizing the state of knowledge on synthetic microbial communities as emerging biotherapeutics, establishing boundaries, mechanisms, and translational challenges without reporting primary experimental results.
Comprehensive narrative review synthesizing microbiome research across multiple biomedical fields without original primary data, serving as expert guidance for clinicians and researchers.