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Fecal Microbiota Transplantation / Disease · Journal article
Gut Microbes · June 12, 2026
A consensus or society position rather than new primary data.
This is a comprehensive narrative review synthesizing microbiome research across gastrointestinal, metabolic, neurological, cardiovascular, autoimmune, and oncological disorders, emphasizing links to precision medicine. The review evaluates microbiome-based therapies including probiotics, prebiotics, fecal microbiota transplantation, and engineered microbial strategies, and examines how microbiomes modulate drug absorption, metabolism, and efficacy.
Journal article. Clinicians, researchers, and life-science professionals seeking comprehensive overview of microbiome dynamics in health and disease.
The human microbiome comprises trillions of bacteria, viruses, fungi, and archaea inhabiting the gut, skin, oral cavity, respiratory tract, and urogenital system Literature search covered publications from 1983 to November 2025 across PubMed, Scopus, Web of Science, Google Scholar, and ScienceDirect Dysbiosis has been linked to inflammatory bowel disease, obesity, type 2 diabetes mellitus, and colorectal cancer
Safety was not reported in the material analysed. Check the source before drawing any conclusion about harm.
This integrative review links microbiome research to precision medicine, emphasizing that safeguarding microbial diversity is crucial for prevention, early diagnosis, and personalization of future medical interventions. The review provides clinicians with a resource for understanding how microbiome profiling influences pharmacokinetics, therapeutic efficacy, and adverse drug reactions.
Comprehensive narrative review synthesizing microbiome research across multiple biomedical fields without original primary data, serving as expert guidance for clinicians and researchers.
As stated by the source record.
Quoted from the source exactly as published.
This integrative review links microbiome research to precision medicine, emphasizing that safeguarding microbial diversity is crucial for prevention, early diagnosis, and personalization of future medical interventions. The review provides clinicians with a resource for understanding how microbiome profiling influences pharmacokinetics, therapeutic efficacy, and adverse drug reactions.
Graded across the dimensions that decide whether you should act, each from what the source actually supports. There is no single score, and where a dimension was not assessed it says so.
The human microbiome, comprising trillions of bacteria, viruses, fungi, and archaea, represents an essential partner in human biology rather than a passive collection of microbes. These microbial communities inhabit diverse niches, including the gut, skin, oral cavity, respiratory tract, and urogenital system, where they contribute to digestion, vitamin biosynthesis, immune development, and regulation of host metabolism. Their dynamic interactions form a complex ecosystem that profoundly shapes health across the lifespan. However, with ever increasing reports on the microbiome including perceived health benefits, diagnostic use, detrimental species and immune modulation, we synthesize findings from multiple biomedical fields for this review. It first describes beneficial functions of commensal microbes in maintaining immune tolerance and metabolic balance, then analyzes the effect of diet, geography and medication exposure, the consequences of dysbiosis in gastrointestinal, metabolic, neurological, cardiovascular, autoimmune, and oncological disorders. The article examines the functional potency of the gut microbiome, keystone taxa as well as disease-stage-specific and general dynamics, how microbiomes modulate drug absorption, metabolism, and efficacy, thereby influencing individualized responses to therapy. Furthermore, it evaluates therapeutic approaches, including probiotics, prebiotics, fecal microbiota transplantation, and engineered microbial strategies that seek to restore microbial equilibrium. The significance of this review lies in its integrative perspective, as it links microbiome research to precision medicine, emphasizing that safeguarding microbial diversity is crucial for prevention, early diagnosis, and the personalization of future medical interventions.
Taken from the source record, never inferred. Follow any of these and new work involving them reaches your briefing.