P. Hariharan*1, G. Hemalatha2, J. Karthi3, S. Swarnalatha4

JUL 19, 2026 · JOURNAL ARTICLE

A Novel Genomic Strategy Against Hyperuricemia: CRISPR-CAS9-Mediated Restoration of Uricase Function from the Human Pseudogene

International Journal of Medical & Pharmaceutical Sciences

First-in-human cell culture demonstration of CRISPR-mediated uricase gene restoration with functional enzyme activity, but lacking animal models, toxicology data, or any human in vivo evidence needed for clinical translation.

JUL 19, 2026 · JOURNAL ARTICLE

A Novel Genomic Strategy Against Hyperuricemia: CRISPR-CAS9-Mediated Restoration of Uricase Function from the Human Pseudogene

International Journal of Medical & Pharmaceutical Sciences

This is a mechanistic proof-of-concept study in cultured cells demonstrating CRISPR-mediated gene integration and enzymatic activity, not a clinical trial or in vivo validation; it raises the question of whether this approach could work therapeutically rather than answering it.