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Researcher

Kathrin Textoris‐Taube

Humboldt-Universität zu Berlin

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JUL 14, 2026 · JOURNAL ARTICLE

Activity-dependent metabolic vulnerability in the APPPS1 Alzheimer’s disease mouse model during isoflurane anesthesia

Biomedicine & Pharmacotherapy

Mechanistic ex vivo study in transgenic mouse brain tissue showing reduced metabolic reserve in Alzheimer's-like pathology during anesthesia; lacks clinical translation and in vivo validation.

PreliminaryKathrin Textoris‐Taube Georg Riepe Intensive Care Unit Cognitive Disorders

Reported

Isoflurane concentrations tested1% and 3%

Primary measurementCerebral metabolic rate of oxygen (CMRO₂)

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