SEP 7, 2026 · JOURNAL ARTICLE
First-line CDK4/6 inhibitor treatment of HR-positive, HER2-negative metastatic breast cancer: real-world data from Ho Chi Minh City Oncology Hospital, Vietnam
Frontiers in Oncology
Retrospective single-center cohort confirming that CDK4/6 inhibitors with endocrine therapy produce PFS and OS outcomes consistent with pivotal trials in HR+/HER2− metastatic breast cancer, but lacks the design rigor and sample size for practice guidance beyond established use.
Reported
Median PFS28.0 months
PFS rate at 12 months66.4%
95% CI for 12-month PFS56.6%–74.4%