AUG 17, 2026 · JOURNAL ARTICLE
Mortality and cardiovascular risk of triglyceride-glucose and derived indices in cardiovascular-kidney-metabolic syndrome stages 0-3: a dose-response meta-analysis
Frontiers in Endocrinology
Rigorous meta-analysis of 80 observational studies with dose-response modelling, clear effect sizes and confidence intervals, but observational design and surrogate indices limit practice-changing status.
Reported
TyG-WC and CVD mortality (highest…RR = 1.52, 95% CI: 1.35–1.70, 95% PI: 1.26–…
CTI and incident CVDRR = 1.57, 95% CI: 1.33–1.85, 95% PI: 1.00–…
TyG-BMI and incident CVDRR = 1.51, 95% CI: 1.36–1.67, 95% PI: 1.05–…