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Fang Liu

Centre for Addiction and Mental Health

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JUL 29, 2026 · JOURNAL ARTICLE

Treatment effects on sphingosine-1-phosphate and its receptors in major depressive disorder: implications for biomarkers

BMC Psychiatry

A single-centre, uncontrolled observational study with modest sample size (n=56 MDD patients) showing biomarker changes in response to treatment and diagnostic discrimination, but lacking a randomized comparator arm and requiring external validation before clinical deployment.

PromisingFang Liu Tryptophan and Brain Disorders Anlong Jiang

Reported

Sample size (MDD patients)56

Sample size (healthy controls)42

Treatment duration8 weeks

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