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Jiaxi Chen

Nanchang University

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SEP 9, 2026 · REVIEW

Survival benefit and toxicity trade-offs of first-line chemoimmunotherapy in advanced gastric and gastroesophageal junction cancer: a meta-analysis of randomized trials

Frontiers in Oncology

A high-quality meta-analysis of 7 RCTs with 6,517 patients showing consistent survival and response benefit for chemoimmunotherapy, but with quantified and clinically relevant toxicity trade-offs that require individualised patient selection.

Strong EvidenceJiaxi Chen Esophageal Cancer Research and Treatment Gastric Cancer Management and Outcomes

Reported

Sample size6517

Number of trials7

Objective response rate – risk ra…1.24

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