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The Japanese Dental Science Review

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JUN 3, 2026 · JOURNAL ARTICLE

Metadherin: A pivotal oncogene and therapeutic target in head and neck cancer - a systematic review.

The Japanese Dental Science Review

This is a systematic review of 33 observational and experimental studies with no randomized controlled trials or clinical outcome data, synthesizing preclinical and correlative evidence that MTDH is overexpressed in HNC and promotes oncogenic functions, but lacking direct evidence of clinical benefit from MTDH-directed intervention.

PreliminarySak Lee Head and Neck Cancer Thantrira Porntaveetus

Reported

Inter-reviewer agreement (Cohen's…0.91

Number of miRNAs regulating MTDH…9

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