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SEP 29, 2026 · JOURNAL ARTICLE
The International Journal of Medical Science and Health Research
Introduction: Bipolar affective disorder with a severe depressive episode and psychotic features is a high-risk clinical state characterised by marked suicidality, prolonged morbid
AUG 16, 2026 · JOURNAL ARTICLE
The International Journal of Medical Science and Health Research
Systematic review of 27 RCTs and observational studies (>180,000 participants) with high GRADE certainty for 11 domains, demonstrating consistent semaglutide benefit across hard endpoints (MACE, mortality, kidney disease, hepatic histology) with low risk of bias in 20/24 RCTs, though industry sponsorship and population representation limit generalizability.