AUG 16, 2026 · JOURNAL ARTICLE
A Comprehensive Systematic Review of the Role of Semaglutide Anti-Obesity Therapy in Multiple Metabolic Diseases: A Systematic Review of Randomized Controlled Trials and Primary Studies
The International Journal of Medical Science and Health Research
Systematic review of 27 RCTs and observational studies (>180,000 participants) with high GRADE certainty for 11 domains, demonstrating consistent semaglutide benefit across hard endpoints (MACE, mortality, kidney disease, hepatic histology) with low risk of bias in 20/24 RCTs, though industry sponsorship and population representation limit generalizability.
Reported
Weight reduction with semaglutide…–14.9% to –16.0%
Weight reduction with placebo–2.4% to –5.7%
Weight reduction p-valueP<0.001