Signal Transduction and Targeted Therapy

OCT 22, 2026 · JOURNAL ARTICLE

Arrhythmic events and genetic variants as drivers for Takotsubo Syndrome: a patient-specific atrial stem-cell model

Signal Transduction and Targeted Therapy

Abstract Takotsubo Syndrome (TTS) is an acute, potentially life-threatening condition often complicated by ventricular dysfunction and arrhythmias. Atrial fibrillation (AF) is comm

OCT 18, 2026 · JOURNAL ARTICLE

Oncogenic mutations in non-small cell lung cancer: from molecular mechanisms to clinical practice

Signal Transduction and Targeted Therapy

Targeted therapy has revolutionized the treatment of non-small cell lung cancer (NSCLC) patients harboring oncogenic alterations, and next-generation tyrosine kinase inhibitors (TK

OCT 16, 2026 · JOURNAL ARTICLE

Next-generation natural killer cell therapy: bench to bedside and beyond

Signal Transduction and Targeted Therapy

Natural killer (NK) cells have emerged as central players in cancer immunotherapy, progressing from basic discovery to clinically validated platforms over five decades. This review

OCT 14, 2026 · JOURNAL ARTICLE

Camrelizumab plus chemotherapy as induction therapy followed by concurrent chemoradiotherapy and camrelizumab consolidation in limited-stage small cell lung cancer: a randomized phase II trial

Signal Transduction and Targeted Therapy

Definitive chemoradiotherapy followed by immunotherapy consolidation is the current standard of care for limited-stage small cell lung cancer (LS-SCLC). We conducted a randomized p

OCT 13, 2026 · JOURNAL ARTICLE

Pulmonary nodules: classification, biomarkers, signaling pathways, diseases, early diagnosis and management

Signal Transduction and Targeted Therapy

Abstract Pulmonary nodules are increasingly detected by thoracic imaging and low-dose computed tomography-based lung cancer screening, but most are benign, transient, or indolent.

OCT 8, 2026 · JOURNAL ARTICLE

Metabolic immune checkpoints (MICs) in cancer: from molecular mechanisms to challenges and opportunities in clinical translation

Signal Transduction and Targeted Therapy

Abstract Metabolic reprogramming is a core feature of tumor cells in adapting to microenvironmental stress and acquiring malignant phenotypes. It not only supports rapid proliferat

SEP 30, 2026 · JOURNAL ARTICLE

Cell differentiation-related signaling pathways: biological functions, diseases and therapeutic targets

Signal Transduction and Targeted Therapy

Cell differentiation, the process by which stem cells acquire specialized functions, underpins embryonic development, tissue homeostasis, and regeneration. This process is governed

SEP 28, 2026 · JOURNAL ARTICLE

Transcriptional intermediary factor 1 gamma-based multitarget gene therapeutic strategy for triple-negative breast cancer

Signal Transduction and Targeted Therapy

Abstract Triple-negative breast cancer (TNBC) is an aggressive subtype lacking effective targeted therapies. A multitarget gene therapy was developed and validated to overcome mole