Source

Russian Journal of Bioorganic Chemistry

3 developments in the corpus

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SEP 4, 2026 · JOURNAL ARTICLE

Modern Challenges of Antimicrobial Resistance and Innovative Approaches to the Treatment of Bacterial Infections

Russian Journal of Bioorganic Chemistry

This is a narrative review synthesizing scientific literature on antimicrobial resistance mechanisms and treatment approaches, offering expert perspective rather than reporting original trial data or clinical evidence.

Expert GuidanceN. L. Klyachko A.V. Lopukhov I. M. Le-Deygen

Study details

DesignNarrative review

SEP 4, 2026 · JOURNAL ARTICLE

Pyoluteorin Production Drives the Antimicrobial-Potentiating Activity of Alpaca Oral Microbiota Components

Russian Journal of Bioorganic Chemistry

This is a mechanistic screening study identifying a microbial metabolite and its in vitro antimicrobial properties; it raises a question about potential therapeutic synergy rather than testing an intervention in a clinical or translational trial.

Hypothesis-GeneratingG. P. Popova L.T.D. Nguyen M. Yu. Zhitlov

Reported

Pyoluteorin IC502.0 ± 0.3 μg/mL

Sub-cytotoxic concentration tested1.5 μg/mL

Magnitude of enhancement to polym…order of magnitude

JUL 28, 2026 · JOURNAL ARTICLE

Dual Cholinesterase Inhibition and Antimicrobial Activity of 4-Aminoantipyrine-Derived Schiff Bases for the Management of Alzheimer’s Disease and Microbial Infections

Russian Journal of Bioorganic Chemistry

This is an early-stage chemical synthesis and in vitro screening study with no animal or clinical data; it raises the question whether these compounds merit further development but does not yet answer whether they are safe or effective in disease.

Hypothesis-GeneratingVISHAL ZAMBRE Pronoy Kanti Das Prasenjit Prasad

Reported

AChE IC50 (PSD2)2.71 µM

AChE IC50 (galantamine reference)20.3 µM

AChE selectivity ratio (PSD2)10.62