Leukemia

OCT 1, 2026 · JOURNAL ARTICLE

ROR1 upregulation after CD19-CAR T-cell relapse in mantle cell lymphoma identifies a targetable vulnerability for ROR1-directed bispecific modalities

Leukemia

BTK inhibition and CD19-directed chimeric antigen receptor (CAR) T-cell therapy represent essential treatments for relapsed/refractory (R/R) mantle cell lymphoma (MCL) and have ach

AUG 18, 2026 · JOURNAL ARTICLE

Modeling KRAS mutations in KMT2A::MLLT3 acute myeloid leukemia promotes leukemic progression and transcriptional rewiring

Leukemia

A mechanistic preclinical model study with supporting clinical cohort data showing KRAS mutations accelerate KMT2A::MLLT3 AML progression; limited by in vivo mouse model design and observational patient data without controlled comparison.

AUG 18, 2026 · JOURNAL ARTICLE

Mutant TP53 allelic states in human hematopoietic stem and progenitor cells

Leukemia

In vitro CRISPR-engineered model system in cord blood HSPCs demonstrating differential effects of TP53 allelic states on colony formation and chromosomal instability, but lacking clinical outcome data or in vivo validation.