Journal of Enzyme Inhibition and Medicinal Chemistry

OCT 16, 2026 · JOURNAL ARTICLE

Optimisation and mechanistic characterization of a selective benzoxazine-based MAP4K4 inhibitor in pancreatic cancer cells.

Journal of Enzyme Inhibition and Medicinal Chemistry

Pancreatic ductal adenocarcinoma (PDAC) remains a lethal malignancy with limited targeted therapeutic options. Mitogen-activated protein kinase kinase kinase kinase 4 (MAP4K4) has

SEP 28, 2026 · JOURNAL ARTICLE

Molecular insights into triazole-based compounds for triple-negative breast cancer treatment.

Journal of Enzyme Inhibition and Medicinal Chemistry

Triple-negative breast cancer (TNBC) is an aggressive breast cancer subtype lacking oestrogen, progesterone, and HER2 receptors, thus limiting the effectiveness of targeted therapi

AUG 4, 2026 · JOURNAL ARTICLE

Context matters in PROTAC design: navigating the trade-off between degradation and developability.

Journal of Enzyme Inhibition and Medicinal Chemistry

This is a narrative review article that synthesizes existing knowledge and proposes a conceptual framework for PROTAC design; it does not present new primary experimental data, clinical outcomes, or empirical validation of its recommendations.

JUN 22, 2026 · JOURNAL ARTICLE

Nanozymes: bridging nanoscale characteristics and catalytic mechanisms for advanced biomedical applications.

Journal of Enzyme Inhibition and Medicinal Chemistry

Comprehensive mechanistic review synthesizing nanozyme catalytic principles and biomedical applications without presenting original experimental data or clinical trials.