AUG 13, 2026 · JOURNAL ARTICLE
Metabolic Dysfunction After Initiation of Androgen Receptor Pathway Inhibitors in Prostate Cancer
JAMA Oncology
Large retrospective cohort study with 16,924 patients showing nearly 40% cumulative incidence of metabolic syndrome within one year of ADT-ARPI initiation; well-characterized population and clear clinical outcome with age-stratified analysis, though observational design and lack of unexposed comparator limit causal inference.
Reported
Cumulative incidence of metabolic…nearly 40%
Incidence of metabolic syndrome,…51.7 events per 1000 person-months
95% CI for incidence, ages 70–79…50.7–53.9