Genome Biology

JUL 27, 2026 · JOURNAL ARTICLE

Accurate prediction of CRISPR editing outcomes in somatic cell lines and zygotes with few-shot learning with inDecay

Genome Biology

A novel computational tool for predicting CRISPR outcomes, demonstrated across multiple cell types and embryo models but lacking clinical validation, prospective efficacy data, or comparison to established methods.

JUL 22, 2026 · JOURNAL ARTICLE

Decoding 3D chromatin architecture reveals distinct enhancer classes underlying hierarchical gene regulation in prostate cancer

Genome Biology

Mechanistic study using CRISPR perturbations and chromatin profiling to explore enhancer function in prostate cancer, raising questions about hierarchical gene regulation but lacking clinical endpoints or validated therapeutic translation.