A narrative mini-review synthesizing biological rationale, clinical trial experience, and emerging strategies for oncofetal antigen-targeted CAR-T therapies, offering expert perspective on opportunities and limitations rather than novel empirical findings.
A mechanistic study using a novel animal model to elucidate developmental pathways in a rare disorder; generates testable hypotheses about TCF4 function but does not provide clinical evidence or human validation.
A comprehensive narrative review synthesizing mechanisms, delivery strategies, and clinical applications of multiple RNA therapeutic modalities, not a primary empirical study.
An in vitro hiPSC-derived keratinocyte model establishing mechanistic links between KRT5 variants and inflammatory pathways, with a proposed but unvalidated therapeutic target in a disease without prior direct clinical evidence.
Mechanistic exploratory study using reanalysis of existing microarray data and single-cell sequencing to propose a miRNA cluster as a driver of breast tumor dedifferentiation; no clinical outcome or intervention trial conducted.
This is a narrative review summarizing design strategies and emerging biomaterial approaches for osteomyelitis; it raises questions about clinical translation rather than reporting new evidence or trials.