Experimental Neurology

JUL 15, 2026 · JOURNAL ARTICLE

Forty-hertz auditory stimulation restored hippocampal-prefrontal synchrony and attenuated hippocampal hyperexcitability in an STZ-induced Alzheimer's model.

Experimental Neurology

A controlled preclinical study in an animal AD model showing reversal of multiple network and molecular abnormalities with 40 Hz stimulation; sound design but limited to rodents and requires confirmation in humans.

JUL 10, 2026 · JOURNAL ARTICLE

Development and characterization of a novel transgenic strain to selectively label neurons that degenerate in 5xFAD mice.

Experimental Neurology

This is a preclinical mechanistic study developing a novel transgenic tracking platform in mice, demonstrating proof-of-concept for labeling degenerating neurons but lacking clinical translation or therapeutic outcome data.

JUL 10, 2026 · JOURNAL ARTICLE

40 Hz-rTMS modulates spike-LFP coupling and improves cognitive function in 5xFAD mice.

Experimental Neurology

First in vivo characterization of spike-LFP coupling in AD model with single-arm intervention study; mechanistic findings in transgenic mice require confirmation in larger, controlled trials before clinical translation.

JUL 3, 2026 · JOURNAL ARTICLE

Neuropathological and functional impact of astrocyte-derived extracellular vesicles in an aged model of Alzheimer's disease.

Experimental Neurology

An uncontrolled mechanistic study in a transgenic mouse model using human-derived extracellular vesicles as a pooled intervention, with modest neuropathological changes and no primary clinical endpoint, requires confirmation before clinical translation.

JUN 24, 2026 · JOURNAL ARTICLE

Trem2 R47H mutation shows mild, but functionally divergent alterations in microglial phenotypes compared to Trem2 deficiency in aged AppNL-F knock-in mice.

Experimental Neurology

Mechanistic study in transgenic mice identifying divergent microglial phenotypes between R47H variant and null mutation; no clinical endpoint or human validation provided.

JUN 5, 2026 · JOURNAL ARTICLE

Animal models of multi-infarct dementia: Methodological approaches, neuropathology, functional outcomes, and translational relevance.

Experimental Neurology

A systematic review synthesizing methodological approaches and limitations of animal models for multi-infarct dementia, providing guidance on model selection and design rather than reporting novel experimental evidence.

MAY 28, 2026 · JOURNAL ARTICLE

Isoquercetin-ligustrazine co-polymorph attenuates hypoxia-accelerated Alzheimer's disease by suppressing PERK-CHOP-mediated ER stress.

Experimental Neurology

Preclinical study in transgenic mice demonstrating mechanism of a novel compound on hypoxia-accelerated AD pathology, without clinical translation or comparative efficacy data.

MAY 27, 2026 · JOURNAL ARTICLE

Evaluation of the neuroprotective effects of ergosterol in a streptozotocin-induced Alzheimer's disease rat model: Insights into anti-inflammatory and antioxidant mechanisms.

Experimental Neurology

Animal model study with in-silico support showing ergosterol reduces oxidative stress and neuroinflammation in STZ-induced rat AD; no human data, mechanistic insight only, and lacks quantified effect sizes with confidence intervals.