Experimental Neurology

OCT 9, 2026 · JOURNAL ARTICLE

Circulating microRNAs reflect hemorrhagic MRI markers in cerebral amyloid angiopathy.

Experimental Neurology

Background. Cerebral amyloid angiopathy is a major cause of intracerebral hemorrhage in older individuals. Although cerebral microbleeds (CMBs) and cortical superficial siderosis (

OCT 1, 2026 · JOURNAL ARTICLE

Alzheimer's disease-associated presenilin 2 N141I mutation impairs neuronal lipid homeostasis and mitochondrial dynamics through selective downregulation of the Golgi exchange factor Gbf1.

Experimental Neurology

Presenilin 2 (PS2) mutations cause familial Alzheimer's disease, yet their effects beyond amyloid processing remain poorly understood. Here, we investigated how PS2 deletion and th

SEP 19, 2026 · JOURNAL ARTICLE

Prenatal origins of neurodegeneration: The role of maternal immune activation in Alzheimer's and Parkinson's pathobiology.

Experimental Neurology

Recent evidence suggests that prenatal environmental factors, particularly maternal infection or maternal immune activation (MIA), may influence the progression of brain aging and

SEP 18, 2026 · JOURNAL ARTICLE

Dynamic contributions of astrocytes in Alzheimer's disease.

Experimental Neurology

In Alzheimer's disease, pathological stimuli reshape astrocyte functions, which in turn act on neurons, making astrocytes critical modulators of disease progression. A comprehensiv

SEP 17, 2026 · JOURNAL ARTICLE

Deletion of NLRP3 gene blocks traumatic brain injury induced abnormal immune response in mice with a genetic background for AD.

Experimental Neurology

Traumatic brain injury (TBI) is a significant risk factor for the development of Alzheimer's disease (AD) and related dementia. In both TBI and AD, inflammation plays a pivotal rol

AUG 26, 2026 · JOURNAL ARTICLE

Non-linear association of blood urea nitrogen with low cognitive performance: Translational evidence from murine models and human population analysis.

Experimental Neurology

Cross-species translational study with human observational data showing a novel non-linear association, but limited by lack of prospective design, mechanistic uncertainty, and authors' own call for validation in independent cohorts.

AUG 10, 2026 · JOURNAL ARTICLE

Let-7d-5p improves mouse cognitive function by targeting bach1 in Alzheimer's disease.

Experimental Neurology

A sound mechanistic study in transgenic mice and cell culture demonstrating let-7d-5p improves cognitive function via bach1 targeting, but lacking human evidence, powered comparison group, or a primary endpoint with effect size and confidence interval.

AUG 9, 2026 · JOURNAL ARTICLE

Alzheimer's disease as a disorder of time-gated clearance: Circadian regulation of Glymphatic function in neurodegeneration.

Experimental Neurology

A mechanistic review and conceptual framework proposing temporal dysregulation of glymphatic clearance in Alzheimer's disease, without new experimental data or clinical evidence to test the hypothesis.