Experimental & Molecular Medicine

OCT 7, 2026 · JOURNAL ARTICLE

Cell plasticity in cancer and therapy resistance

Experimental & Molecular Medicine

Abstract Cancer cell plasticity, the ability of tumor cells to switch between distinct cellular states, has emerged as a key mechanism driving tumor progression, metastasis and the

OCT 2, 2026 · JOURNAL ARTICLE

DUSP4 activates adipocyte thermogenesis via CRTC3 dephosphorylation-dependent UCP1 expression

Experimental & Molecular Medicine

Abstract Obesity arises when a chronic energy surplus overwhelms the storage capacity of adipocytes and subsequently causes systemic metabolic dysfunction. Adaptive thermogenesis,

OCT 2, 2026 · JOURNAL ARTICLE

Single-cell epigenomics of colorectal cancer

Experimental & Molecular Medicine

Abstract Colorectal cancer (CRC) exhibits remarkable phenotypic heterogeneity that cannot be fully explained by genetic alterations alone. Advances in single-nucleus assay for tran

SEP 10, 2026 · JOURNAL ARTICLE

Linking visceral fat accumulation to gut microbiota: key bacterial taxa and their roles in the glycogen synthesis pathway

Experimental & Molecular Medicine

Observational cohort analysis linked specific bacterial taxa to visceral fat via metagenomic pathway inference, validated in a single diet-induced obesity mouse model; mechanistic but limited by surrogate endpoints and animal confirmation only.

SEP 8, 2026 · JOURNAL ARTICLE

N-terminal thrombospondin-1 enhances muscle function and tissue-specific metabolic adaptation in response to exercise and cold exposure

Experimental & Molecular Medicine

A mechanistic study combining mouse models and human correlation data showing N-TSP1 enhances muscle function and metabolic markers, but lacks controlled human trials and relies on surrogate endpoints and observational human data.

AUG 18, 2026 · JOURNAL ARTICLE

The interplay between lipid metabolism, cancer progression and anti-cancer immunity

Experimental & Molecular Medicine

This is a narrative review integrating mechanistic concepts and emerging evidence rather than reporting original empirical findings or clinical outcomes; it raises questions about lipid metabolism as a therapeutic target rather than answering them with trial data.

AUG 13, 2026 · JOURNAL ARTICLE

Take Five: harmonization in personalized cancer vaccines for cancer immunotherapy

Experimental & Molecular Medicine

A narrative review synthesizing current evidence on personalized cancer vaccine development, proposing a framework for future optimization rather than reporting original empirical findings.

AUG 5, 2026 · JOURNAL ARTICLE

Macrophage-to-myofibroblast transition-derived itaconate promotes bone metastasis in lung cancer through targeting of HSPA8

Experimental & Molecular Medicine

Mechanistic study in animal models of a proposed metabolic axis in lung cancer bone metastasis; no clinical outcome data, human efficacy trials, or direct comparison to standard therapy reported.