Cancer Biology & Therapy

SEP 21, 2026 · JOURNAL ARTICLE

Fibroblast-associated TPM2 links cell-matrix remodeling to EMT-Notch signaling and gemcitabine resistance in intrahepatic cholangiocarcinoma.

Cancer Biology & Therapy

Intrahepatic cholangiocarcinoma (ICC) is an aggressive liver malignancy with heterogeneous responses to gemcitabine-based chemotherapy. The cellular and microenvironmental programs

SEP 8, 2026 · JOURNAL ARTICLE

Thioredoxin reductase-1 facilitates cellular plasticity and stemness mediated by TGF-β1 in non-small cell lung cancer.

Cancer Biology & Therapy

Mechanistic study in cell lines and a mouse model identifying a pathway without clinical endpoint data or direct evidence of therapeutic benefit in humans.

SEP 8, 2026 · JOURNAL ARTICLE

DNA-PKcs and PARP1 at the interface between DNA damage responses and cGAS-STING signaling: context-dependent roles and therapeutic implications.

Cancer Biology & Therapy

Aims. To explore the roles of DNA-dependent protein kinase catalytic subunit (DNA-PKcs) and poly(ADP-ribose) polymerase 1 (PARP1) in both the DNA damage repair (DDR) pathway and th

AUG 11, 2026 · JOURNAL ARTICLE

The molecular mechanisms of platelets in tumor invasion and metastasis: a controversial role.

Cancer Biology & Therapy

This is a narrative review synthesizing mechanistic evidence on platelet-tumor interactions without reporting primary experimental or clinical data, clinical endpoints, or quantified effect sizes.

JUL 28, 2026 · JOURNAL ARTICLE

DNA polymerase theta (Polθ): a novel candidate for targeted cancer therapy.

Cancer Biology & Therapy

A narrative review synthesizing current knowledge on Polθ biology, therapeutic rationale, and drug development status—informative for researchers and clinicians but not reporting original empirical data or trial outcomes.

JUL 28, 2026 · JOURNAL ARTICLE

Molecular interplay of insulin resistance and cancer: advances in monoclonal antibody therapeutics.

Cancer Biology & Therapy

This is a narrative review proposing mechanistic connections between insulin resistance and cancer, with speculative discussion of monoclonal antibody therapeutics, but no primary experimental or clinical data to support efficacy claims.

JUL 27, 2026 · JOURNAL ARTICLE

Stress-specific 14-3-3-client modules in digestive cancers: an evidence-graded review of adaptive survival and therapy resistance.

Cancer Biology & Therapy

Narrative review synthesizing mechanistic evidence from functional studies in digestive cancers; no new primary data, clinical validation limited, and therapeutic translation not yet established.

JUL 26, 2026 · JOURNAL ARTICLE

Targeting molecular and genetic pathways driving tumorigenesis for precision therapy in colorectal cancer.

Cancer Biology & Therapy

This is a narrative review synthesizing existing knowledge about molecular pathways in colorectal cancer and therapeutic strategies, without presenting new primary data, clinical trials, or original findings to evaluate.