A methodologically sound single-centre internal validation study of prognostic nomograms with good discrimination (C-index 0.74–0.76) in a contemporary HER2-positive metastatic cohort, but limited by lack of specific treatment annotation and short median follow-up relative to the 5-year outcome estimates.
A narrative review synthesizing epidemiology, transmission dynamics, and public health challenges across a region, offering integrated surveillance recommendations within a One Health framework rather than reporting new empirical evidence.
A large, well-designed retrospective cohort study with robust methods (inverse-probability weighting, competing-risks analysis) that confirms the absence of a clinically meaningful difference in circulatory mortality between treatment sequences, with narrow confidence intervals crossing the null.