Most cases of autosomal dominant polycystic kidney disease (ADPKD) are caused by mutations in PKD1, which reduce polycystin-1 (PC1) levels below a critical functional threshold. No
This is a narrative review synthesizing mechanistic evidence from preclinical models and observational studies to propose pathways linking developmental exposures to adult cardiometabolic disease, but it does not report original empirical findings or comparative efficacy data.