American Journal of Physiology-endocrinology and Metabolism

SEP 23, 2026 · JOURNAL ARTICLE

Exercise-mimicking effect of exogenous lactate administration: Promoting visceral fat reduction via ventromedial hypothalamic SF-1 neurons in female rats

American Journal of Physiology-endocrinology and Metabolism

Lactate, a metabolic product of high-intensity training, may possess exercise-mimicking effects that promote fat loss via the hypothalamic-adipose axis, yet its neuronal targets re

SEP 3, 2026 · JOURNAL ARTICLE

Additive effects of metformin on glucose homeostasis after metabolic-bariatric surgery in non-obese insulin-deficient diabetic rats

American Journal of Physiology-endocrinology and Metabolism

Preclinical animal study in a non-obese diabetic rat model that raises mechanistic questions about metformin and bariatric surgery combination; not designed to inform human clinical practice.

AUG 17, 2026 · JOURNAL ARTICLE

Mechanistic Drivers of Thermogenic Adipose Tissue Dysfunction in Aging and Obesity

American Journal of Physiology-endocrinology and Metabolism

A narrative review synthesizing mechanistic pathways in preclinical and cell biology without reporting clinical trials, patient outcomes, or quantified human data; raises questions about regulatory mechanisms rather than answering them in humans.