Acs Pharmacology & Translational Science

SEP 23, 2026 · JOURNAL ARTICLE

Mechanism-Guided Combination Pharmacology of Curcumin and Methotrexate: Translational Strategies in Cancer and Emerging Applications in Rheumatoid Arthritis

Acs Pharmacology & Translational Science

Abstract Methotrexate (MTX) remains a cornerstone therapy in oncology and, to a lesser extent, rheumatoid arthritis (RA), yet its clinical utility in both settings is constrained b

SEP 12, 2026 · JOURNAL ARTICLE

Gut Microbial Metabolism Inactivates Trifluridine and Drives Loss of Anticancer Efficacy

Acs Pharmacology & Translational Science

Abstract Human-associated gut bacteria harbor diverse genetic and metabolic potential. Orally administered therapeutic drugs can interact with these bacteria in the gastrointestina

SEP 10, 2026 · JOURNAL ARTICLE

Quantitative Systems Pharmacology Model Predicts Enhanced Antitumor Efficacy of Combined Cytotoxic T-Lymphocyte-Associated Protein 4 (CTLA-4) and Programmed Cell Death Protein 1 (PD-1) Blockade in a Syngeneic Mouse Model of Breast Cancer

Acs Pharmacology & Translational Science

A mechanistic computational model of checkpoint-inhibitor combinations in mice that predicts synergy but lacks experimental validation of the proposed mechanisms in humans and does not address clinical efficacy or safety.

AUG 14, 2026 · JOURNAL ARTICLE

The Lipid Switch:Ultra-High Dose Omega Fatty AcidsDetermine MYCN Neuroblastoma Fate and Implicate Substrate-LevelOxylipin Competition

Acs Pharmacology & Translational Science

Mechanistic preclinical study in a syngeneic mouse model showing lipid-dependent tumor fate; no human data, no clinical outcomes, and the proposed dietary intervention mechanism requires confirmation in humans.