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Mood Disorders / Anxiety Disorders / Healthy Volunteers · Observational Study
ClinicalTrials.gov · August 11, 2026
Early or partial results. Treat as a signal, not a conclusion.
This is an ongoing observational screening protocol at NIMH designed to characterise patients with mood and anxiety disorders and healthy volunteers for eligibility in downstream research studies. No clinical outcomes, treatment effects, or results are reported in this registry record; it documents only the study design, procedures, and recruitment status.
Observational. Mood Disorders, Anxiety Disorders, Healthy Volunteers, Bipolar Disorder, Depression; age from 3 Years; to 99 Years; accepts healthy volunteers. Intervention: Adult Healthy Volunteers; Adult Patients; Minor Healthy Volunteers; Minor Patients; Parents of Minor Healthy Volunteers; Parents of Minor Patients. n = 16,000. 1 site: United States.
This is an ongoing observational screening protocol at NIMH designed to characterise patients with mood and anxiety disorders and healthy volunteers for eligibility in downstream research studies. No clinical outcomes, treatment effects, or results are reported in this registry record; it documents only the study design, procedures, and recruitment status.
Safety was not reported in the material analysed. Check the source before drawing any conclusion about harm.
This is a screening tool and registry study, not a treatment or diagnostic validation study. It does not provide evidence to guide clinical practice; it serves as a recruitment and characterisation instrument for NIMH research protocols.
This is a screening and natural history registry study with no reported results; it describes protocol methodology and participant characterization only, without outcome data or comparative analyses.
As stated by the source record.
Quoted from the source exactly as published.
This is a screening tool and registry study, not a treatment or diagnostic validation study. It does not provide evidence to guide clinical practice; it serves as a recruitment and characterisation instrument for NIMH research protocols.
Graded across the dimensions that decide whether you should act, each from what the source actually supports. There is no single score, and where a dimension was not assessed it says so.
What is missing. This record has no key findings. That is a gap in the analysis, not a judgement about the study.
Registry record from ClinicalTrials.gov (NCT00024635). This is a study registration, not published results. Lead sponsor: National Institute of Mental Health (NIMH). Recruitment status: RECRUITING. Study type: OBSERVATIONAL. Enrollment: 16000 participants (ESTIMATED). Conditions: Mood Disorders, Anxiety Disorders, Healthy Volunteers, Bipolar Disorder, Depression. Primary outcome measures: Eligibility for research , Current and historical. Brief summary: The purpose of this protocol is to allow for the careful screening of patients and healthy volunteers for participation in research protocols in the Experimental Therapeutics and Pathophysiology Lab (ETPB) at the National Institute of Mental Health (NIMH) and for the collection of natural history data. In addition the protocol will allow clinicians to gain more experience in the use of a variety of polysomnographic and high-density EEG recordings. Subjects in this protocol will undergo an evaluation which may include: a psychiatric interview; a diagnostic interview; rating scales; a medical history; a physical exam; brain magnetic resonance imaging (MRI); electroencephalography (EEG); electrocardiography (EKG), magnetoencephalography (MEG); blood, saliva and urine laboratory evaluation; and a request for medical records. Subjects may also be asked to complete questionnaires about attitudes towards research and motivation for research participation. The data collected may also be linked with data from other mood and anxiety disorder protocols (e.g., brain imaging, DNA, psychophysiology tests, treatment studies, etc) for the purposes of better understanding the diagnosis, pathophysiology, and treatment response of patients with mood disorders. Parents of minors will be interviewed. Upon conclusion of the screening process, subjects will either be offered participation in a research protocol and will sign the appropriate informed consent, or will be considered not appropriate for participation in research and will be referred back into the community. The current protocol thus serves as an entry point for individuals with mood or anxiety disorders or healthy volunteers to enter NIMH IRB approved ETPB protocols.
Taken from the source record, never inferred. Follow any of these and new work involving them reaches your briefing.