Loading
Lung Cancer Diagnosis and Treatment / Cancer Research and Treatments · Journal article
Molecular Cancer · August 15, 2026
Raises a question worth testing. It does not answer one.
This narrative review proposes the intratumoral microbiome as a fundamental and variable feature of the tumor microenvironment and a potential therapeutic target in cancer. The source synthesizes conceptual frameworks and discusses roles in tumor biology, biomarkers, and therapy response, but presents no original data, meta-analysis, or systematic evidence evaluation to support specific clinical recommendations.
Journal article. Literature review covering intratumoral microbiome across different cancer types; no specific patient cohort studied..
The number of microbial communities identified within tumors has increased by 400% over the past decade. The intratumoral microbiome—including bacteria, fungi, viruses, and other microorganisms—was first discovered more than a century ago but remains characterized by low biomass, complicating functional study.
Safety was not reported in the material analysed. Check the source before drawing any conclusion about harm.
The source did not state who this applies to in practice.
This is a narrative review proposing the intratumoral microbiome as a conceptual framework and therapeutic target, without presenting original primary data or systematic evidence synthesis to support specific clinical claims.
Quoted from the source exactly as published.
Graded across the dimensions that decide whether you should act, each from what the source actually supports. There is no single score, and where a dimension was not assessed it says so.
Over the past decade, the number of microbial communities identified within tumors has increased by 400%. Notably, the intratumoral microbiome, which includes bacteria, fungi, viruses, and other microorganisms within tumor tissues, was first discovered more than a century ago. Based on the updated framework of cancer characteristics, we propose that the immune microenvironment is a fundamental and variable microbial feature in cancer. Numerous studies have demonstrated that the intratumoral microbiome constitutes a critical component of the tumor microenvironment. However, due to its low biomass, characterizing its functional mechanisms remains a significant challenge. To summarize current research on the intratumoral microbiome in oncology, we first examine its establishment, homeostasis, and heterogeneity across different cancer types, followed by a comprehensive exploration of its multifaceted roles in tumor initiation and progression. Furthermore, we discuss the critical implications of the intratumoral microbiome in cancer biomarkers, antitumor therapies, and novel microbe-based anticancer strategies. In summary, this review highlights the intratumoral microbiome as an emerging therapeutic target, offering new perspectives for deciphering the complex mechanisms of cancer.
Taken from the source record, never inferred. Follow any of these and new work involving them reaches your briefing.