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DLPFC-insula TMS / sham TMS / Heart Brain Coupling · Interventional Study
ClinicalTrials.gov · August 7, 2026
Early or partial results. Treat as a signal, not a conclusion.
This is a registered, active clinical trial examining whether personalized TMS targeting of brain connectivity circuits modulates heart-brain coupling in individuals with depressive tendencies. The study is mechanistic in focus and no results have been posted to the registry; the evidence is therefore preliminary and cannot yet inform clinical practice.
Interventional, Randomized, Crossover, Single masking, Basic Science purpose. Depression Disorder, fMRI Research, Heart-Brain Coupling; age from 18 Years; to 30 Years; accepts healthy volunteers. Intervention: Personalized stimulation targeting the functional connectiv…; Personalized stimulation targeting DLPFC-insula functional…; Standard F3 Target Stimulation. Compared with: sham stimulation — Sham Comparator. n = 60. 1 site: China.
This is a registered, active clinical trial examining whether personalized TMS targeting of brain connectivity circuits modulates heart-brain coupling in individuals with depressive tendencies. The study is mechanistic in focus and no results have been posted to the registry; the evidence is therefore preliminary and cannot yet inform clinical practice.
This is a registry record with no results posted; no efficacy or safety data are available.
The source did not state who this applies to in practice.
This is a registered interventional study of personalized TMS targeting in depression that is actively recruiting with no results posted; it describes planned methodology only.
As stated by the source record.
Quoted from the source exactly as published.
Graded across the dimensions that decide whether you should act, each from what the source actually supports. There is no single score, and where a dimension was not assessed it says so.
What is missing. This record has no key findings. That is a gap in the analysis, not a judgement about the study.
Registry record from ClinicalTrials.gov (NCT07753473). This is a study registration, not published results. Lead sponsor: Xidian University. Recruitment status: RECRUITING. Phase: NA. Study type: INTERVENTIONAL. Enrollment: 60 participants (ESTIMATED). Conditions: Depression Disorder, fMRI Research, Heart-Brain Coupling. Interventions: DEVICE: DLPFC-insula TMS; DEVICE: DLPFC-sgACC TMS; DEVICE: 10-20 F3 TMS; DEVICE: sham TMS. Primary outcome measures: TMS-induced heart-brain coupling , Perioperative. During the 7-minute-22-second treatment period under each stimulation condition.; Phase-amplitude coupling , Perioperative period. Specifically, within 10 minutes before and after each stimulus condition.; Heartbeat-evoked potentials , Perioperative period. Specifically, within 10 minutes before and after each stimulus condition.. Brief summary: This study focuses on individuals with depressive tendencies and investigates the regulatory effects of Transcranial Magnetic Stimulation (TMS)-guided by personalized functional connectivity mapping-on heart-brain coupling in this population, while also exploring the underlying mechanisms.Participants will undergo 3T functional magnetic resonance imaging (fMRI) scans, followed by four different types of neurostimulation: stimulation targeting individualized Dorsolateral Prefrontal Cortex (DLPFC) -Subgenual Anterior Cingulate Cortex (sgACC) functional connectivity, stimulation targeting individualized DLPFC-insula functional connectivity, standard F3 targeting, and sham stimulation. The order of these stimulation sessions will be randomized. Researchers will simultaneously record the participants' electroencephalogram (EEG) and electrocardiography (ECG) signals before and after stimulation, and will record ECG in real-time during the stimulation. The primary objective of this study is to investigate the effects of DLPFC targeting specificity on metrics such as heart-brain coupling in individuals with depressive tendencies, thereby providing a basis for future research on objective assessment and personalized interventions for depression.
Taken from the source record, never inferred. Follow any of these and new work involving them reaches your briefing.