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Normal and Abnormal Cardiovascular Physiology · Observational Study
ClinicalTrials.gov · September 8, 2026
Early or partial results. Treat as a signal, not a conclusion.
This is a registry record documenting an active, multi-arm observational study sponsored by the NHLBI to develop and refine CMR imaging sequences and assess gadolinium retention in the brain. No results are posted in this registry record; the study is currently recruiting and outcomes remain exploratory and ongoing.
Observational. Normal and Abnormal Cardiovascular Physiology; age from 7 Years; to 100 Years; accepts healthy volunteers. Intervention: Assessing Gadolinium deposition within the brain in healthy…; Child Patient or Healthy Child; Healthy Volunteers; Research Patients Cardiac and Non Cardiac. n = 5,000. 1 site: United States.
This is a registry record documenting an active, multi-arm observational study sponsored by the NHLBI to develop and refine CMR imaging sequences and assess gadolinium retention in the brain. No results are posted in this registry record; the study is currently recruiting and outcomes remain exploratory and ongoing.
Safety was not reported in the material analysed. Check the source before drawing any conclusion about harm.
The source did not state who this applies to in practice.
This is an active observational registry study with no results posted; it describes technical and translational development of CMR methods with exploratory endpoints including sequence development and gadolinium deposition assessment.
As stated by the source record.
Quoted from the source exactly as published.
Graded across the dimensions that decide whether you should act, each from what the source actually supports. There is no single score, and where a dimension was not assessed it says so.
What is missing. This record has no key findings. That is a gap in the analysis, not a judgement about the study.
Registry record from ClinicalTrials.gov (NCT03581318). This is a study registration, not published results. Lead sponsor: National Heart, Lung, and Blood Institute (NHLBI). Recruitment status: RECRUITING. Study type: OBSERVATIONAL. Enrollment: 5000 participants (ESTIMATED). Conditions: Normal and Abnormal Cardiovascular Physiology. Primary outcome measures: Translational development of MRI sequences , on going; Technical development of MRI sequences , on going; Evaluating the correlation , on going; Assesment of Gad deposition in the brain , on going. Brief summary: Background: Magnetic resonance imaging (MRI) is an important non-invasive tool to study and diagnose cardiovascular disease. MRI scanners use strong magnetic fields and radio waves to create pictures of body organs. Researchers want to find better MRI methods and new ways of imaging cardiovascular disease and better understand normal and abnormal cardiovascular and brain function. Researchers are also interested in seeing if gadolinium, the commonly used MRI contrast agent, stays in the body long after the MRI was performed. Objectives: To develop new methods for imaging the heart and other organs of the body. To describe cardiovascular diseases using newer MRI methods To look at the relationship between cardiovascular disease and cardiovascular risk factors and other organ systems To look for gadolinium deposits in the brain from prior exams. Eligibility: Healthy people and people with known or suspected cardiovascular disease ages 7 and older may be eligible for this study. Researchers may be particularly interested in those who: * Have suspected or known cardiovascular disease * Were previously exposed to a gadolinium-based contrast agent, * Need to have a heart MRI scheduled * Need a test of the heart or other body part or will be undergoing a future cardiac catheterization Design: There are multiple arms to the study with optional components; therefore, there are multiple variations as to what an individual participant s experience may involve. Participants will have an MRI scan lasting up to 2 hours. The scanner is a large hollow tube. During the scan, there may be loud knocking and buzzing sounds caused by the scanner. Participants will lie on a table that slides in and out of the tube. Their vital signs may be monitored. Participants may have a test of heart electrical activity using wires connected to pads on the skin. Participants may have blood drawn. Participants may be injected with an MRI contrast agent through a plastic tube inserted in the arm.
Taken from the source record, never inferred. Follow any of these and new work involving them reaches your briefing.