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Obesity / Li Fraumeni Syndrome / NSR IDE-MRI: Research pulse sequences · Observational Study
ClinicalTrials.gov · August 17, 2026
Early or partial results. Treat as a signal, not a conclusion.
This is a clinical trial registry record for an ongoing observational study sponsored by the NHLBI designed to characterize cardiovascular disease phenotypes and risk factors across metabolic, inflammatory, and genetic conditions in up to 5,000 participants aged 1–100 years. No results have been posted in this registry record; the study is still recruiting and outcome data are not yet available.
Observational. Metabolic Disease, Obesity, Li-Fraumeni Syndrome, Cardiomyopathy, Atherosclerosis, Inflammatory Disease; age from 1 Year; to 100 Years; accepts healthy volunteers. Intervention: 1. Adult index cases and relatives; 2. Child index case and child relatives; 3. Healthy adult volunteers. n = 5,000. 3 sites: United States.
This is a clinical trial registry record for an ongoing observational study sponsored by the NHLBI designed to characterize cardiovascular disease phenotypes and risk factors across metabolic, inflammatory, and genetic conditions in up to 5,000 participants aged 1–100 years. No results have been posted in this registry record; the study is still recruiting and outcome data are not yet available.
Safety was not reported in the material analysed. Check the source before drawing any conclusion about harm.
The source did not state who this applies to in practice.
This is an ongoing observational registry study with no reported results; it characterizes enrollment and study design only, providing no outcome data or clinical evidence.
As stated by the source record.
Quoted from the source exactly as published.
Graded across the dimensions that decide whether you should act, each from what the source actually supports. There is no single score, and where a dimension was not assessed it says so.
What is missing. This record has no key findings. That is a gap in the analysis, not a judgement about the study.
Registry record from ClinicalTrials.gov (NCT01143454). This is a study registration, not published results. Lead sponsor: National Heart, Lung, and Blood Institute (NHLBI). Recruitment status: RECRUITING. Study type: OBSERVATIONAL. Enrollment: 5000 participants (ESTIMATED). Conditions: Metabolic Disease, Obesity, Li-Fraumeni Syndrome, Cardiomyopathy, Atherosclerosis, Inflammatory Disease. Interventions: DEVICE: NSR IDE-MRI: Research pulse sequences. Primary outcome measures: Disease Diagnosis , Ongoing. Brief summary: Background: \- Researchers are interested in studying individuals who have known or suspected metabolic, inflammatory or genetic diseases that may put them at a high risk for heart diseases or diseases of their blood vessels. Depending on the condition being studied, both affected and nonaffected individuals may be asked to provide blood and other samples and may undergo tests to evaluate the heart, blood vessels and lung function. The testing is tailored to the individual and/or condition being studied. Nonaffected individuals may include relatives of affected individuals and healthy nonrelated volunteers. Objectives: \- To study individuals who have or are at risk for cardiovascular diseases, and in some cases their unaffected relatives and healthy volunteers. Eligibility: \- Individuals between 1 and 100 years of age. Participants may be healthy volunteers, individuals with cardiovascular diseases, or unaffected relatives of individuals with cardiovascular diseases. Design: * Participants will have some or all of the following tests, as directed by the study researchers: * Photography of the face and full body * Body measurements * Radiography, including chest or limb x-rays * Metabolic stress testing to study heart and muscle function * Echocardiography to study heart function * Magnetic resonance imaging (MRI) studies, including cardiovascular MRI, angiography, and contrast MRI, to study heart function and performance * Computed tomography (CT) angiogram to obtain images of the heart and lungs * Positron emission tomography (PET) imaging to study possible fat infiltration of the heart * Six-minute walk test to study heart, lung, and muscle function and performance * Vascular ultrasound to study blood vessel walls * Blood, tissue, and other specimens will be collected for research and testing, and will be taken either as part of the clinical study or during surgical procedures. * Follow-up studies may be performed under separate research protocols.
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