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Acute Lymphoblastic Leukemia Research / Chemotherapy-induced Cardiotoxicity and Mitigation / Childhood Cancer Survivors' Quality of Life · Journal article
Child`s Health · August 7, 2026
Early or partial results. Treat as a signal, not a conclusion.
This single-centre cross-sectional study documents the frequency of late endocrine complications in 50 childhood ALL survivors treated with chemotherapy alone, finding overweight/obesity (32%), prediabetes (12%), and short stature (6%) as the main complications. The lack of a control group and modest sample size mean this is descriptive surveillance data suitable for hypothesis generation rather than definitive evidence of treatment effect or risk.
Non-randomized, analytic cross-sectional study. Patients diagnosed with ALL between March 2011 and February 2020 at the Pediatric Hemato-Oncology Center, Children's Central Teaching Hospital, Baghdad, Iraq, who had achieved complete remission for at least 2 years.. Intervention: Chemotherapy-only regimen for childhood ALL. n = 50. Single centre: Pediatric Hemato-Oncology Center, Children's Central Teaching Hospital, Baghdad, Iraq.
Overweight and obesity identified in 16 patients (32%), significantly associated with age younger than 5 years at diagnosis (p = 0.044) Prediabetes detected in 6 patients (12%), showing significant association with overweight and obesity (p = 0.009) Short stature observed in 3 patients (6%)
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This study highlights that metabolic complications, particularly overweight/obesity and prediabetes, are frequent in chemotherapy-treated ALL survivors and warrant routine screening. However, the single-centre design and lack of control comparison limit the strength of any conclusions about treatment attribution or the generalizability of prevalence estimates to other populations.
Single-centre cross-sectional study with modest sample size describing frequencies of endocrine complications in ALL survivors; provides descriptive data but lacks a comparator group and cannot establish causation or generalizability.
As stated by the source record.
Quoted from the source exactly as published.
This study highlights that metabolic complications, particularly overweight/obesity and prediabetes, are frequent in chemotherapy-treated ALL survivors and warrant routine screening. However, the single-centre design and lack of control comparison limit the strength of any conclusions about treatment attribution or the generalizability of prevalence estimates to other populations.
Graded across the dimensions that decide whether you should act, each from what the source actually supports. There is no single score, and where a dimension was not assessed it says so.
Background. Modern treatment protocols for childhood acute lymphoblastic leukemia (ALL) have greatly improved survival; however, a growing number of survivors experience late endocrine complications as a consequence of treatment. The purpose was to evaluate the spectrum and frequency of late endocrine complications in childhood ALL survivors managed with a chemotherapy-only regimen. Materials and methods. A non-randomized, analytic cross-sectional study was conducted on 50 patients diagnosed with ALL between March 2011 and February 2020 at the Pediatric Hemato-Oncology Center, Children’s Central Teaching Hospital, in Baghdad, Iraq. All participants had achieved complete remission for at least 2 years. Clinical and laboratory investigations were performed to identify late endocrine complications. Results. Overweight and obesity were identified in 16 patients (32 %) and were significantly associated with age younger than 5 years at diagnosis (p = 0.044). Short stature was observed in 3 patients (6 %). Prediabetes was detected in 6 patients (12 %) and showed a significant association with overweight and obesity (p = 0.009). Subclinical hypothyroidism and delayed puberty were each detected in one patient (2 %). No significant associations were found between short stature, prediabetes, thyroid dysfunction, or delayed puberty with respect to age or sex. Conclusions. Overweight and obesity were the most frequent endocrine late complications among childhood ALL survivors and were associated with younger age at diagnosis. Prediabetes was more common in overweight and obese patients, highlighting the importance of long-term metabolic surveillance in this population.
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