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Cancer Research and Treatment / Hydrogen's Biological and Therapeutic Effects · Journal article
International Journal of Surgery Protocols · August 11, 2026
Early or partial results. Treat as a signal, not a conclusion.
This is a protocol document describing a planned prospective single-arm feasibility trial of preoperative home-based hydrogen gas inhalation in patients undergoing liver resection. No results are presented; the study aims to assess safety, protocol adherence, and generate preliminary data for future randomized trials.
Prospective, single-center, single-arm, open-label exploratory clinical trial. Patients scheduled for liver resection during the preoperative waiting period.. Intervention: Home-based hydrogen gas inhalation during sleep and approximately 1 hour each morning and evening for 14 consecutive days preoperatively.. n = 8. Single-center; Japan Registry of Clinical Trials registration (jRCTs062250073) suggests Japan-based setting..
This is a protocol document describing a planned prospective single-arm feasibility trial of preoperative home-based hydrogen gas inhalation in patients undergoing liver resection. No results are presented; the study aims to assess safety, protocol adherence, and generate preliminary data for future randomized trials.
Safety was not reported in the material analysed. Check the source before drawing any conclusion about harm.
This protocol document does not yet provide clinical evidence; it describes the framework for a feasibility study. Clinicians should await results before considering hydrogen gas inhalation in preoperative practice.
Protocol for a single-arm feasibility study with no results yet reported; designed to generate preliminary data for future trial design rather than test efficacy.
As stated by the source record.
Quoted from the source exactly as published.
This protocol document does not yet provide clinical evidence; it describes the framework for a feasibility study. Clinicians should await results before considering hydrogen gas inhalation in preoperative practice.
Graded across the dimensions that decide whether you should act, each from what the source actually supports. There is no single score, and where a dimension was not assessed it says so.
What is missing. This record has no key findings. That is a gap in the analysis, not a judgement about the study.
Introduction: Hydrogen therapy has been reported to exert antioxidative and anti-inflammatory effects and has attracted increasing clinical interest across various medical fields. In cancer treatment, a waiting period often exists between the treatment decision and surgery; however, structured and evidence-based preoperative interventions during this interval remain limited. Home-based hydrogen gas inhalation, which enables long-duration, repeated administration, may represent a feasible and practical strategy for preoperative optimization. This study aims to evaluate the safety and feasibility of a standardized home-based hydrogen gas inhalation protocol in patients scheduled for liver resection. Methods: This is a prospective, single-center, single-arm, open-label exploratory clinical trial with a planned enrollment of eight participants. Eligible patients scheduled for liver resection will undergo home-based hydrogen gas inhalation during sleep and, additionally, for approximately 1 hour each morning and evening for 14 consecutive days in the preoperative waiting period. The primary endpoint is feasibility, defined as protocol adherence based on predefined inhalation duration criteria. Safety will be assessed by the incidence of adverse events. Secondary and exploratory assessments include changes in inflammation-related, immune-related, and nutrition-related indices, oxidative stress markers, body composition parameters, questionnaire-based quality of life, and tumor markers. This study is registered in the Japan Registry of Clinical Trials (jRCT: jRCTs062250073). Conclusion: This study protocol is designed to evaluate the feasibility and safety of preoperative home-based hydrogen gas inhalation and to generate preliminary data to inform the design of subsequent clinical trials investigating its potential role in perioperative care for liver surgery.
Taken from the source record, never inferred. Follow any of these and new work involving them reaches your briefing.