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Cancer Research and Treatment / Nanoparticles: Synthesis and Applications · Journal article
Bangladesh Journal of Infectious Diseases · September 8, 2026
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This is an in vitro proof-of-concept study describing chemical synthesis and characterization of PEG-coated silver nanoparticles (Ag NPs) and their inhibitory activity against multidrug-resistant E. coli using a disk diffusion method. The work is preclinical and mechanistic; it demonstrates that the nanoparticles show an inhibitory effect qualitatively but reports no quantitative antimicrobial metrics, no sample size or replication, and no direct comparison with antibiotics.
Uncontrolled in vitro experimental study. Multidrug-resistant Escherichia coli strains (bacterial); conducted in an in vitro laboratory setting.. Intervention: PEG-coated silver nanoparticles (Ag NPs) synthesized by chemical reduction method, 50 nm diameter, spherical morphology. Compared with: Conventional antibiotics (not specified by name or quantitative result). Department of Applied Biotechnology, College of Biotechnology, Al-Qasim Green University, Iraq.
Ag NPs synthesized by chemical reduction method and coated with PEG confirmed by SEM and UV-Vis spectrophotometry at 410 nm wavelength SEM imaging showed spherical Ag NPs with approximately 50 nm diameter PEG-coated Ag NPs demonstrated inhibitory effect against multidrug-resistant Escherichia coli in vitro using hole diffusion assay
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In vitro experimental study of nanoparticle synthesis and characterization with antimicrobial testing against a single bacterial strain; no clinical data, comparative quantification, or validation in relevant systems.
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Background: The nano state of silver nanoparticles (Ag Nps), have made it possible to enhance the antimicrobial properties of silver ions, which are widely used in various mediations specially antimicrobials. Objectives: The study was aimed to synthesize Ag Nps using chemical coating with PEG, characterize it and assess their antimicrobial activity against MDR Escherichia coli. Methodology: An experimental study was carried out in the Department of Applied Biotechnology, College of Biotechnology, Al-Qasim Green University, Iraq. From October 2024 to February 2025. Ag Nps have been prepared using the chemical reduction method and coated with PEG, the resulted Ag Nps was confirmed using SEM and Uv-Vis Spectrophotometer, a Multiple Drug Resistance E-coli have been used to assess the inhibitory effect of the obtained Ag Nps using an in vitro hole diffusion approach. Results: A golden color was formed after adding the reducing agent to the silver salt, confirming the formation of Ag Nps, Uv-Vis Spectrophotometer obtained at 410, SEM have shown spherical shape with about 50 nm in diameter. Compared with various antibiotics, Ag Nps coated PEG had shown an enhanced ability to inhibit the Gram-negative MDR Escherichia coli. Conclusion: Due to its ultrafine size, Ag Nps coated PEG can provide an enhanced inhibitory effect against MDR Escherichia coli, compared with conventional antibiotics, which may attract the attention of researchers to use it in various medical applications. Bangladesh Journal of Infectious Diseases, June 2026;13(1):203-207
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