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Adipokines, Inflammation, and Metabolic Diseases · Journal article
Applied Biosciences · September 8, 2026
Early or partial results. Treat as a signal, not a conclusion.
This preclinical study demonstrates that Artocarpus integer stem bark extract reduces body weight gain and food intake in high-fat diet-induced obese rats, with effects approaching semaglutide at the highest dose tested, accompanied by improvements in lipid profile, adipokines, and modulation of appetite and lipogenic gene expression. The work provides mechanistic evidence for multi-target action but remains confined to a rodent model and does not establish efficacy or safety in humans.
Single-arm preclinical efficacy study in high-fat diet-induced obese rat model with reference compound comparison. Male Wistar rats with high-fat diet-induced obesity. Intervention: 95% ethanol extract of Artocarpus integer stem bark at 200–800 mg/kg/day, oral administration. Compared with: Semaglutide and resveratrol (reference compounds); HFD control.
High-dose extract (800 mg/kg/day) demonstrated substantial weight-reducing effect approaching magnitude of semaglutide Extract markedly reduced body weight gain, visceral adiposity, and food intake compared to HFD control (p < 0.05) Treatment decreased total cholesterol and triglycerides, increased HDL levels; reduced leptin and amylin, increased adiponectin
No reporting of adverse effects, toxicity, or duration of follow-up in treatment groups
This preclinical result cannot yet guide clinical practice. It suggests A. integer extract warrants investigation in human obesity trials and points to potential mechanistic pathways (appetite signaling, lipid metabolism) that could be exploited therapeutically, but the leap from rodent pharmacology to human efficacy and safety remains substantial.
Single animal model study with mechanistic endpoints and no human data; demonstrates proof-of-concept for anti-obesity effects but requires confirmation in human trials before clinical application.
As stated by the source record.
Quoted from the source exactly as published.
This preclinical result cannot yet guide clinical practice. It suggests A. integer extract warrants investigation in human obesity trials and points to potential mechanistic pathways (appetite signaling, lipid metabolism) that could be exploited therapeutically, but the leap from rodent pharmacology to human efficacy and safety remains substantial.
Graded across the dimensions that decide whether you should act, each from what the source actually supports. There is no single score, and where a dimension was not assessed it says so.
Obesity is a multifactorial metabolic disorder characterized by dysregulated energy homeostasis, impaired lipid metabolism, and altered hypothalamic appetite signaling. This study aimed to evaluate the anti-obesity effects and underlying mechanisms of a 95% ethanol extract of Artocarpus integer stem bark in a high-fat diet (HFD)-induced obese rat model. Obesity was induced in male Wistar rats using HFD feeding, followed by treatment with the extract (200–800 mg/kg/day, oral). Semaglutide and resveratrol were used as reference compounds. Body weight, food intake, adiposity, serum lipid profile, adipokines, histological changes, and gene expression related to lipid metabolism (Fas, Pparγ, Cpt-1, AdipoR1) and hypothalamic appetite regulation (Pomc, Mc4r, Npy) were evaluated. Phytochemical profiling was performed using LC–HRMS. The extract markedly reduced body weight gain, visceral adiposity, and food intake compared with the HFD control (p < 0.05), with the high-dose extract demonstrating a substantial weight-reducing effect that approached the magnitude of semaglutide. Treatment improved dyslipidemia by decreasing total cholesterol and triglycerides while increasing HDL levels. Adipokine imbalance was restored, as evidenced by reduced leptin and amylin and increased adiponectin levels. At the molecular level, the extract downregulated lipogenic genes (Fas, Pparγ), partially restored Cpt-1 expression, and normalized AdipoR1. In the hypothalamus, Pomc and Mc4r were upregulated, whereas Npy was suppressed. LC–HRMS analysis revealed the presence of stilbene, chalcone, and flavonoid derivatives. In conclusion, A. integer stem bark extract exerts anti-obesity effects through coordinated modulation of appetite signaling and lipid metabolism, supporting its potential as a multi-target phytotherapeutic agent for obesity management.
Taken from the source record, never inferred. Follow any of these and new work involving them reaches your briefing.