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Metabolic Syndrome / Asthma / Atherosclerosis · Observational Study
ClinicalTrials.gov · August 7, 2026
Early or partial results. Treat as a signal, not a conclusion.
This is a registry entry for a planned observational study examining innate immune responses to endotoxin exposure in healthy volunteers. No results are reported in this record; the study is currently recruiting.
Observational. Asthma, Atherosclerosis, Metabolic Syndrome, Insulin Resistance, Cancer; age from 18 Years; to 100 Years; accepts healthy volunteers. Intervention: ABCA1; APOE; APOL1; CD14; CD44; IRGM; ITIH3; ITIH4; MyD88; TIRAP; TLR4; TLR5; TNFa. n = 725. 1 site: United States.
This is a registry entry for a planned observational study examining innate immune responses to endotoxin exposure in healthy volunteers. No results are reported in this record; the study is currently recruiting.
This is a registry record with no results posted; no efficacy, safety, or mechanistic findings are available.
The source did not state who this applies to in practice.
This is a registry record describing a planned observational study with no results reported; it documents study design and intended enrollment only.
As stated by the source record.
Quoted from the source exactly as published.
Graded across the dimensions that decide whether you should act, each from what the source actually supports. There is no single score, and where a dimension was not assessed it says so.
What is missing. This record has no key findings. That is a gap in the analysis, not a judgement about the study.
Registry record from ClinicalTrials.gov (NCT01143480). This is a study registration, not published results. Lead sponsor: National Institute of Environmental Health Sciences (NIEHS). Recruitment status: RECRUITING. Study type: OBSERVATIONAL. Enrollment: 725 participants (ESTIMATED). Conditions: Asthma, Atherosclerosis, Metabolic Syndrome, Insulin Resistance, Cancer. Primary outcome measures: The primary endpoints of this study are for both cell types and will be levels of 6 cytokines [TNF alpha, IL-6, MIP-2, IL-8, MCP-1, and IFN-beta (ELISA)] induced by LPS and by PAM3CSK4 plus baseline cytokine levels (no exposure to LPS or PAM3CSK... , After analysis. Brief summary: Background: \- Innate immunity is the process by which white blood cells and other parts of the immune system sense and respond to potential infections by causing an inflammation. Researchers are interested in studying how the body responds to certain environmental factors, and whether the body s response can contribute to chronic illnesses or diseases such as asthma and certain types of cancers. Objectives: \- To examine how specific genes and proteins in blood cells respond to environmental exposures. Eligibility: \- Healthy volunteers between 18 and 45 years of age. Design: * The study will involve one visit of 45 to 60 minutes. * Participants will be screened with a brief physical examination and finger stick to determine if they are eligible to donate blood for the study, and will complete a questionnaire about any medications or other drugs (e.g., cigarettes) they may be taking. * Participants will provide a blood sample for research purposes.
Taken from the source record, never inferred. Follow any of these and new work involving them reaches your briefing.