Tai Chi / Health Education / Hormone Receptor Positive Breast Carcinoma · Interventional Study

Tai Chi for Reducing Aromatase Inhibitor-Induced Arthralgia

ClinicalTrials.gov · August 14, 2026

Preliminary Why this matters to you Expert discussion

Early or partial results. Treat as a signal, not a conclusion.

AI Summary

This is a registered pilot randomized controlled trial comparing Tai Chi to health education for aromatase inhibitor-induced arthralgia in postmenopausal women with hormone receptor-positive breast cancer. No outcomes have been reported in this registry record; the study is currently recruiting and will measure feasibility (consent, engagement, and retention rates) rather than clinical efficacy.

What was studied

Interventional, Randomized, Parallel, Open label, Supportive Care purpose. Hormone Receptor Positive Breast Carcinoma, Postmenopausal, Breast Cancer; Female; age from 18 Years. Intervention: TaiChi4Joint. Compared with: Health Education Attention Control — Active Comparator. n = 40. 1 site: United States.

Key findings

Safety

Safety was not reported in the material analysed. Check the source before drawing any conclusion about harm.

Who this may help

This is a feasibility pilot; no clinical efficacy data are yet available. Results from this study may inform design of a larger efficacy trial if the intervention is acceptable and engagement adequate.

Plain-language summary

This is a study registration for a planned pilot RCT with no results yet reported; it describes feasibility and acceptability endpoints only, not clinical efficacy.

Study design

As stated by the source record.

MethodsPrimary outcome measures: Consent Rate (assessed at Up to 6 months); Engagement Rate (assessed at 12 weeks); Retention Rate (assessed at 20 weeks)

DesignInterventional, Randomized, Parallel, Open label, Supportive Care purpose

PopulationHormone Receptor Positive Breast Carcinoma, Postmenopausal, Breast Cancer; Female; age from 18 Years

Sample size40

InterventionTaiChi4Joint

ComparatorHealth Education Attention Control — Active Comparator

Setting1 site: United States

Reported figures

Quoted from the source exactly as published.

Estimated enrollment40

Primary outcome: Consent RateUp to 6 months

Primary outcome: Engagement Rate12 weeks

Primary outcome: Retention Rate20 weeks

Clinical bottom line

Caveats

This is a registry record; no results are reported.
Primary outcomes are feasibility measures (consent, engagement, retention), not clinical efficacy or symptom relief.
Sample size of 40 is designed for pilot testing, not for drawing efficacy conclusions.
Blinding status and phase classification are not stated; mechanism of action data collection is mentioned but not detailed.

Evidence assessment

Graded across the dimensions that decide whether you should act, each from what the source actually supports. There is no single score, and where a dimension was not assessed it says so.

Study design

moderate

Registered pilot RCT with control arm; phase and blinding status not stated.

Directness

moderate

Addresses aromatase inhibitor-induced arthralgia in target population; outcomes are feasibility not efficacy.

Consistency

insufficient

No results reported; consistency cannot be assessed from a registry record alone.

Risk of bias

insufficient

Study is recruiting; design details insufficient to judge bias risk at this stage.

Sample adequacy

limited

Estimated 40 participants total; appropriate for pilot feasibility study, not efficacy.

What is missing. This record has no key findings. That is a gap in the analysis, not a judgement about the study.

Source abstract

Registry record from ClinicalTrials.gov (NCT07737951). This is a study registration, not published results. Lead sponsor: Thomas Jefferson University. Recruitment status: RECRUITING. Phase: NA. Study type: INTERVENTIONAL. Enrollment: 40 participants (ESTIMATED). Conditions: Hormone Receptor Positive Breast Carcinoma, Postmenopausal, Breast Cancer. Interventions: BEHAVIORAL: Tai Chi; BEHAVIORAL: Health Education. Primary outcome measures: Consent Rate , Up to 6 months; Engagement Rate , 12 weeks; Retention Rate , 20 weeks. Brief summary: The objective of the pilot RCT is to evaluate the feasibility and acceptability of a Tai Chi intervention "TaiChi4Joint" vs. an HE AC group for relieving AIIA in women with hormone receptor positive stage I-III BCa. The investigators will pilot test our data collection for mechanism measures via three innovatively integrated biobehavioral pathways.

Follow from this

Taken from the source record, never inferred. Follow any of these and new work involving them reaches your briefing.

NCT07737951Tai ChiHealth EducationThomas Jefferson UniversityHormone Receptor Positive Breast CarcinomaPostmenopausalBreast Cancer