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RNA, Untranslated / Non-coding Rnas · Journal article
Virulence · August 9, 2026
Raises a question worth testing. It does not answer one.
This narrative review synthesizes evidence for non-coding RNA regulation in dermatophyte pathogenesis and host-fungal crosstalk, focusing on miRNAs, lncRNAs, circRNAs, and tRFs. The authors acknowledge that mechanistic insights derive predominantly from in vitro models with limited in vivo validation, and identify knowledge gaps regarding the relative contribution of individual virulence factors to clinical outcomes.
Narrative review. Individuals with dermatophytosis caused by Trichophyton rubrum, Trichophyton mentagrophytes, and Microsporum canis; review primarily addresses immunocompetent populations.
Dermatophytosis affects 20–25% of immunocompetent individuals globally and ranks as the fourth most common cutaneous infection The T. rubrum species complex accounts for approximately 80–90% of chronic dermatophytosis cases globally Non-coding RNAs constitute more than 90% of the human transcriptome and orchestrate cellular processes through epigenetic, transcriptional, and post-transcriptional regulation
Safety was not reported in the material analysed. Check the source before drawing any conclusion about harm.
This review outlines a roadmap for ncRNA-targeted diagnostics and antifungal therapies but does not provide evidence-based clinical recommendations. Clinicians should recognize this as a conceptual synthesis proposing future directions rather than evidence supporting changed practice.
This is a narrative review synthesizing mechanistic insights from predominantly in vitro studies; it raises questions about ncRNA roles in dermatophytosis but does not present original empirical evidence or clinical trials to answer them.
As stated by the source record.
Quoted from the source exactly as published.
This review outlines a roadmap for ncRNA-targeted diagnostics and antifungal therapies but does not provide evidence-based clinical recommendations. Clinicians should recognize this as a conceptual synthesis proposing future directions rather than evidence supporting changed practice.
Graded across the dimensions that decide whether you should act, each from what the source actually supports. There is no single score, and where a dimension was not assessed it says so.
Dermatophytosis, a prevalent superficial fungal infection caused by fungi such as Trichophyton rubrum, Trichophyton mentagrophytes, and Microsporum canis, develops through the dynamic interaction between fungal virulence factors - including adhesion, secretion of keratinolytic proteases, and hyphal invasion - and the host's multifaceted immune response, which involves antimicrobial peptides, pattern recognition receptors, and cellular immunity. Recent evidence identifies non-coding RNAs (ncRNAs), including miRNAs, lncRNAs, circRNAs, and tRFs, as key regulators of this host-fungal crosstalk. This review synthesizes current advances, showing that dermatophyte infection alters host ncRNA expression while fungi themselves produce stage-specific ncRNAs to modulate virulence genes involved in protease activity, nutrient acquisition, and hyphal growth. We highlight the dual role of ncRNAs in both promoting host defense and facilitating fungal invasion, linking fungal pathogenicity to immune modulation. Finally, we explore the translational potential of targeting ncRNA networks, outlining a roadmap for novel mechanism-based diagnostics and antifungal therapies against this widespread, recurrent infection.
Taken from the source record, never inferred. Follow any of these and new work involving them reaches your briefing.