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Researcher

Shi Yin

Anhui Key Laboratory of Geriatric Immunology and Nutrition Therapy, Hefei, 230027, China; Department of Geriatrics, Division of Life Sciences and Medicine, The First Affiliated Hospital of USTC, University of Science and Technology of China

1 development in the corpus

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JUL 27, 2026 · JOURNAL ARTICLE

Bioactive molecule-derived covalent organic frameworks as biocompatible scaffolds for targeted AKR1B10 inhibition in alcoholic liver disease.

Biomaterials

This is a preclinical study combining transcriptomic analysis, virtual screening, and chemical synthesis followed by testing in animal models, raising mechanistic questions about AKR1B10 and COF scaffolds rather than establishing clinical efficacy.

Hypothesis-GeneratingMicrornas Jialu Zhuang Juan Wang

Reported

ALD patient cohort size33

Healthy control cohort size23

Number of inhibitors identified4

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