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Jialu Zhuang

Department of Oncology, The First Affiliated Hospital of Anhui Medical University, Hefei, 230022, China; Department of Pharmacology, School of Pharmacy, Anhui Medical University, Hefei, 230032, China; Zhongda Hospital & Cancer Institute (Xu

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JUL 27, 2026 · JOURNAL ARTICLE

Bioactive molecule-derived covalent organic frameworks as biocompatible scaffolds for targeted AKR1B10 inhibition in alcoholic liver disease.

Biomaterials

This is a preclinical study combining transcriptomic analysis, virtual screening, and chemical synthesis followed by testing in animal models, raising mechanistic questions about AKR1B10 and COF scaffolds rather than establishing clinical efficacy.

Hypothesis-GeneratingMicrornas Jialu Zhuang Juan Wang

Reported

ALD patient cohort size33

Healthy control cohort size23

Number of inhibitors identified4

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