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J. Thomas Brenna

The University of Texas at Austin

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AUG 14, 2026 · JOURNAL ARTICLE

The Lipid Switch:Ultra-High Dose Omega Fatty AcidsDetermine MYCN Neuroblastoma Fate and Implicate Substrate-LevelOxylipin Competition

Acs Pharmacology & Translational Science

Mechanistic preclinical study in a syngeneic mouse model showing lipid-dependent tumor fate; no human data, no clinical outcomes, and the proposed dietary intervention mechanism requires confirmation in humans.

Hypothesis-GeneratingCancer, Lipids, and Metabolism Eicosanoids and Hypertension Pharmacology John T. Powers

Reported

Tumor incidence with arachidonic…100%

Tumor mass ratio (arachidonic aci…4-fold larger

Mean tumor size ratio (docosahexa…22%

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