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Paolo Palma

Bambino Gesù Children's Hospital

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JUL 28, 2026 · JOURNAL ARTICLE

Advanced Machine Learning Across Multiple Vaccines to Predict Durable Immunogenicity using the Immune Signatures Data Resource 2260430

The Journal of Immunology

This is a post-hoc exploratory machine-learning analysis of observational transcriptomic and immunological data identifying correlates of antibody durability across vaccines, without prospective validation or clinical outcome prediction in a held-out cohort.

Hypothesis-GeneratingJing Chen Ofer Levy Viral Infections and Outbreaks Research

Reported

Sample size (total healthy adults)1405

Number of vaccines analysed24

Variance in antibody response exp…∼15%

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