Jian Li

SEP 2, 2026 · JOURNAL ARTICLE

Loss of function of ALDH3B2 transdifferentiates human pancreatic duct cells into β-like cells

Science Translational Medicine

A single-centre, mechanistic study identifying a gene target for β-cell transdifferentiation with proof-of-concept in primary human cells and mouse transplantation, but lacking human clinical data and requiring confirmation in larger systems.

AUG 10, 2026 · PREPRINT

Dual-Adversarial Safety Alignment: Cultivating Intrinsic Threat Comprehension in LRMs

arXiv

A methodological paper proposing a novel training framework for LRM safety with empirical results on synthetic jailbreak robustness, but lacking peer review, clinical or real-world validation, and independent confirmation.

AUG 5, 2026 · JOURNAL ARTICLE

Clinical application value of metagenomic next-generation sequencing in children with fever of unknown origin

Frontiers in Pediatrics

Single-center retrospective analysis of 41 children with uncontrolled selection bias (only tested after conventional failure), no control arm, and equivalence to standard testing rather than superiority; generates descriptive data warranting prospective validation.