Following this puts new work involving it at the top of your briefing, with a note saying why it is there. Links are taken from the source record, never inferred.
In vitro mechanistic study demonstrating synergy between pyrimidine analogs and β-lactams in MRSA via cell wall precursor pathway modulation, with potential for repurposing anticancer drugs, but requiring in vivo validation before clinical application.
Rigorous nationwide retrospective cohort study with propensity score matching, large sample size, and consistent effect across multiple analytical approaches and subgroups, establishing a clinically significant increased risk of PJP with ICIs in lung cancer.
A rigorous single-center interrupted time-series study with a large effect size and sustained improvement in a clinically relevant surrogate endpoint, but limited generalizability and requiring multicenter confirmation.
Retrospective descriptive epidemiology from a single calendar year with no clinical outcomes, control group, or intervention; establishes pathogen prevalence patterns but cannot determine causation, severity, or practice-relevant associations.
Laboratory-based genomic surveillance study characterizing antimicrobial resistance profiles in invasive K. pneumoniae isolates; descriptive epidemiology without a comparator or intervention, providing foundational data on resistance patterns and risk factors in a single region.
Retrospective surveillance analysis describing seasonal patterns and temporal shifts in respiratory virus positivity across Ontario hospitals, without a comparator group or formal hypothesis testing, representing descriptive epidemiology.
Retrospective observational study documenting established epidemiological patterns of respiratory viruses across defined time periods; confirms known shifts in viral detection during COVID-19 pandemic but uses descriptive methods without novel intervention or causal inference.