SEP 8, 2026 · JOURNAL ARTICLE
Purine and pyrimidine analogs differentially regulate cell wall precursor biosynthesis to control β-lactam susceptibility in methicillin-resistant Staphylococcus aureus
mBio
In vitro mechanistic study demonstrating synergy between pyrimidine analogs and β-lactams in MRSA via cell wall precursor pathway modulation, with potential for repurposing anticancer drugs, but requiring in vivo validation before clinical application.
Study details
DesignIn vitro mechanistic study with transcripto…
InterventionPyrimidine analogs (5-fluorouracil, 5-fluor…
Comparator6-thioguanine (purine analog) as a contrast…