AUG 12, 2026 · JOURNAL ARTICLE
Cutaneous immune-related adverse events independently predict overall survival with a grade-dependent association in ICI-treated advanced NSCLC: a time-dependent analysis
Frontiers in Oncology
Retrospective cohort study with rigorous time-dependent Cox analysis addressing immortal time bias, demonstrating independent OS benefit of cutaneous irAE in advanced NSCLC, but single-institution design and small grade 3+ subgroup limit immediate generalizability.
Reported
Primary endpoint – Overall surviv…HR = 0.52
95% confidence interval for OS HR0.35–0.78
P-value for OS association0.002