DNA Repair Mechanisms

SEP 5, 2026 · JOURNAL ARTICLE

Covalent Targeting and Thermostabilization of Oncogenic R280K and R273H Mutants p53 by Small Molecule RVJB59

Chemmedchem

In vitro mechanistic study of a small molecule binding to mutant p53 domains, with no cell-based or clinical data, raising a question about therapeutic potential rather than demonstrating it.

AUG 17, 2026 · JOURNAL ARTICLE

Emerging roles of ATR beyond DNA damage repair: orchestrating transcriptional reprogramming during epithelial-to-mesenchymal transition

Journal of Clinical Investigation

This is a journal commentary synthesizing two concurrent primary studies; it raises mechanistic questions about ATR's role in EMT and metastasis but does not itself present original empirical data or a definitive clinical trial result.

AUG 14, 2026 · JOURNAL ARTICLE

Inhibition of ATM, ATR and DNA-PK radiosensitises 3D uveal melanoma models to X-rays and proton beam therapy

Frontiers in Oncology

Sound experimental study in 3D models demonstrating that DNA damage response inhibitors enhance radiosensitivity to both X-rays and proton therapy, but limited to in vitro spheroids without clinical validation or human data.

AUG 12, 2026 · JOURNAL ARTICLE

Mitoxantrone synergies with tigecycline against Klebsiella pneumoniae

Microbiology Spectrum

Mechanistic and proof-of-concept work in vitro and in a murine model identifying a drug repurposing opportunity; lacks human efficacy data and clinical validation needed to support practice change.

AUG 10, 2026 · JOURNAL ARTICLE

Suppression of transcription-replication conflicts by sequence-coordinated actions of TRDMT1 and MutLα

Nature Communications

Mechanistic study identifying a synthetic lethal interaction and demonstrating in vivo tumor suppression, but limited to cell lines and xenografts without clinical efficacy data.