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Xiaojuan Ran

Duke University

1 development in the corpus

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AUG 10, 2026 · JOURNAL ARTICLE

Suppression of transcription-replication conflicts by sequence-coordinated actions of TRDMT1 and MutLα

Nature Communications

Mechanistic study identifying a synthetic lethal interaction and demonstrating in vivo tumor suppression, but limited to cell lines and xenografts without clinical efficacy data.

PromisingArijit Ghosh Xiaojuan Ran Yu Xu

Reported

MutLα componentsMLH1 or PMS2

MMR complexity scopeMutLβ and MutSα/β dispensable for TRDMT1i r…

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